ADC may refer to:

• ADC Aircraft, a British firm established in 1920
• ADC Airlines, based in Ikeja, Nigeria
• Aerospace Defense Command, of the U.S. Air Force
• Air data computer, an essential avionics component found in modern glass cockpits
• IATA airport code for Andakombe Airport in Eastern Highlands Province, Papua New Guinea

• ADC Theatre, venue of the University of Cambridge Amateur Dramatic Club
• Art Directors Club of New York, a professional association
• Australian Dance Council, a national dance advocacy organisation
• Hong Kong Arts Development Council, a statutory body in Hong Kong

• Aboriginal Development Commission, an Australian statutory body that existed from 1980 to 1990
• African Democratic Congress, a political party in Nigeria
• Alliance for Democratic Change, a political party in Tanzania
• American-Arab Anti-Discrimination Committee, a civil rights organization
• American Deserters Committee, an anti-Vietnam War group
• Arizona Department of Corrections, US
• Arkansas Department of Correction, US
• Ashfield District Council, Nottinghamshire, England
• Asociación Democrática de Colima, a political party from the State of Colima, Mexico

• Acadia Divinity College, a seminary on the campus of Acadia University, Canada
• ADC Map, an American map publisher
• ADC Telecommunications, in Eden Prairie, Minnesota
• Australian Defence College, Weston Creek, Canberra
• Advanced Digital Corporation, a defunct computer company of Southern California

• ADC (gene), a human gene
• AIDS dementia complex, neurological disorder associated with HIV and AIDS
• Allyl diglycol carbonate or CR-39, a polymer
• Antibody-drug conjugate, a type of anticancer treatment
• Apparent diffusion coefficient, a derived value from a diffusion MRI
• Automated dispensing cabinet, a computerized drug storage device for hospitals
• Azodicarbonamide, a blowing agent

• Advanced Data Connector, a Microsoft technology
• Advanced Direct Connect, a peer-to-peer file sharing and chat protocol
• Analog-to-digital converter, a type of electronic circuit
• Android Developer Challenge, a competition
• Apple Developer Connection, Apple Computer's developer network
• Apple Display Connector, similar to the DVI connector
• Application delivery controller, for accelerating website performance
• Automatic Data Capture, for automatic identification, data collection and storage into computer systems

• A.DC., taxonomic author abbreviation for Alphonse Pyramus de Candolle (1806–1893), French-Swiss botanist
• Adlington (Cheshire) railway station, UK (National Rail code)
• Aide-de-camp, assistant to a senior military or government person
• Aid to Dependent Children, an American government social program from 1935 to 1960
• Alternative Daily cover, material other than soil for containment in a landfill
• Andrew Dice Clay (born 1957), American comedian
• Axiom of dependent choice
• New Zealand ADC class diesel multiple unit, a type of diesel railway vehicle used on Auckland's suburban network