Zapotec (English: /ˈsɒpoʊˌtɛk/) or zapoteca may refer to:

• Zapotec civilization, a historical indigenous pre-Columbian civilization and archaeological culture of central Mexico
• Zapotec languages, a group of closely related indigenous Mesoamerican languages
• Zapotec peoples, contemporary indigenous peoples of Mexico
• Zapotecan languages, a group of related Oto-Manguean languages (including Zapotec languages), of central Mesoamerica
• Zapotec language (Jalisco), an extinct language from Jalisco state in Mexico, unrelated (despite its name) to the group of Zapotec languages.

• Zapoteca (plant), a legume genus

• Emil Zátopek, athlete from Czechoslovakia
  • Zátopek (film), a 2021 Czech film about him
• Lukáš Zátopek, Czech ice hockey player