William Sheppard may refer to:

• Bill Sheppard (footballer) (1906–1950), English association footballer.
• Bill Sheppard (music producer), American R&B producer of the 1950s and 60s
• William Sheppard (barrister) (died 1674), English legal writer
• William Sheppard (painter) (fl. 1660s), English painter
• William Sheppard (trainer) (1855–1932), racehorse trainer in South Australia
• William Sheppard (baseball), American baseball player
• William Fleetwood Sheppard, Australian-British mathematician and statistician
• William Henry Sheppard, African-American Presbyterian missionary famous for revealing Belgian atrocities in the Congo Free State
• W. Morgan Sheppard (1932–2019), William Morgan Sheppard, British actor, sometimes credited as Morgan Sheppard
• William Bostwick Sheppard (1860–1934), U.S. federal judge

• William Shepard (disambiguation)
• William Shepherd (disambiguation)