The following discussion is an archived debate of the proposed deletion of the article below. Please do not modify it. Subsequent comments should be made on the appropriate discussion page (such as the article's talk page or in a deletion review). No further edits should be made to this page.

The result was keep. No consensus to delete. The issue of what to merge into what can continue on the various talk pages. (non-admin closure) Ron Ritzman (talk) 22:58, 30 May 2009 (UTC)[reply]

Enzyme induction and inhibition (edit | talk | history | protect | delete | links | watch | logs | views) (delete) – (View log)

This page appears to be about two un-linked articles and only redirects to one of them, however a few pages link here: Special:WhatLinksHere/Enzyme_induction_and_inhibition Captain n00dle ^T/_C 14:22, 17 May 2009 (UTC)[reply]

Relisted to generate a more thorough discussion so consensus may be reached.
Please add new comments below this notice. Thanks, Ron Ritzman (talk) 00:00, 24 May 2009 (UTC)[reply]

• Comment: For relevant context, see Wikipedia:Redirects for discussion/Log/2009 May 24#Enzyme induction and inhibition. Cunard (talk) 18:13, 24 May 2009 (UTC)[reply]
• I oppose as per the link above: A merger with enzyme inhibitor was previously discussed in 2006 but it seems it has now been redirected without discussion to the featured article on enzyme inhibitor (see history; contains a lot of good content that shouldn't just be deleted). There is no article with a good discussion of enzyme induction, and enzyme inhibitor does not discuss gene expression inhibition. I suggest that we restore this article and let it focus on gene expression inhibition and induction, which is not discussed anywhere else. --Steven Fruitsmaak (Reply) 18:36, 24 May 2009 (UTC)[reply]
• Weak Keep. Weak as I'm not an expert on the subject matter, but this article is referenced and has incoming links, and it seems that it is covering a different topic from enzyme inhibitor. Robofish (talk) 04:34, 27 May 2009 (UTC)[reply]
• Merge to Drug metabolism#Factors that affect Drug Metabolism. The two concepts of induction and inhibition are distinct, however there seems to be use of them together as a phrase (solely) in the field of pharmacology to describe factors affecting drug metabolising enzymes, see e.g. [1], [2], [3]. To the best of my knowledge, there is no current usage of the phrase "enzyme induction" in molecular biology – whilst it was historically used e.g. in the case of the lactose system of E. coli – it has been replaced by the more general concept of gene expression regulation since Jacob/Monod. Celefin (talk) 16:04, 27 May 2009 (UTC)[reply]

I'd suggest xenobiotic metabolism as a merge target instead of just drug metabolism, since the concept applies to more compounds than just drugs. Tim Vickers (talk) 16:17, 27 May 2009 (UTC)[reply]

I would probably merge xenobiotic metabolism and drug metabolism, but that's another discussion. Celefin (talk) 20:25, 27 May 2009 (UTC)[reply]

There is some overlap certainly and the current xenobiotic metabolism article doesn't cover the wider topic as well as it could, but persistent organic pollutant degradation or pesticide and herbicide metabolism are very important topics that wouldn't easily fit under the heading of "drugs". Tim Vickers (talk) 20:44, 27 May 2009 (UTC)[reply]

• Keep, but move to enzyme induction (which is currently a redirect) and rewrite to focus only on the usage of this term in xenobiotic metabolism, which remains quite common eg PMID 18991590. "Enzyme inhibition" is very rarely used as a term for the suppression of enzyme gene expression, since this is much too easily confused with activity-based inhibition. See for example this paper on drug auto-inhibition of a P450. Here the term is only used to describe interactions between the drug and this enzyme, but not changes in the expression level of the enzyme. Similarly in PMID 18690879, which is a review that covers both topics and again uses induction to refer to changes in gene expression and inhibition to refer to direct drug-enzyme interactions. Tim Vickers (talk) 16:22, 27 May 2009 (UTC)[reply]
• Note: This debate has been included in the list of Medicine-related deletion discussions. —WhatamIdoing (talk) 17:38, 27 May 2009 (UTC)[reply]

The above discussion is preserved as an archive of the debate. Please do not modify it. Subsequent comments should be made on the appropriate discussion page (such as the article's talk page or in a deletion review). No further edits should be made to this page.