USS Yorktown may refer to the following ships of the United States Navy:

• USS Yorktown (1839), a 16-gun sloop-of-war commissioned in 1840 (sunk in 1850)
• USS Yorktown (PG-1), the lead Yorktown-class gunboat commissioned in 1889 (sold in 1921)
• USS Yorktown (CV-5), the lead Yorktown-class aircraft carrier commissioned in 1937 (sunk in 1942)
• USS Yorktown (CV-10), an Essex-class aircraft carrier commissioned in 1943 (museum ship since 1975)
• USS Yorktown (CG-48), a Ticonderoga-class cruiser commissioned in 1984 (undergoing scrapping)