Theodora Komnene or Comnena (Greek: Θεοδώρα Κομνηνὴ) may refer to:

• Theodora Komnene (daughter of Alexios I) (born 1096), daughter of Alexios I Komnenos, wife of Constantine Angelos and ancestor of the Angelos dynasty
• Theodora Despina Komnene, daughter of John IV of Trebisond and consort of Aq Qoyunlu's ruler Uzun Hasan
• Theodora Komnene Dalassene, sister of Alexios I Komnenos, wife of Constantine Diogenes II
• Theodora Komnene, Queen of Jerusalem (born c. 1145), niece of Manuel I Komnenos, wife of Baldwin III of Jerusalem
• Theodora Komnene, Duchess of Austria (died 1184), niece of Manuel I Komnenos, wife of Henry II, Duke of Austria
• Theodora Komnene, Princess of Antioch (fl. 1140), niece of Manuel I Komnenos, wife of Bohemond III of Antioch