(The) Last Man on Earth may refer to:

• Last Man on Earth (book), science fiction anthology edited by Isaac Asimov
• Last Man on Earth (album), a 2001 album by Loudon Wainwright III
• "The Last Man on Earth" (song), a 2021 song by Wolf Alice from their album Blue Weekend
• The Last Man on Earth (1924 film), a silent comedy film
• The Last Man on Earth (1964 film), an Italian science fiction film starring Vincent Price
• The Last Man on Earth (2011 film), an Italian science fiction film by Gipi
• The Last Man on Earth (TV series), a 2015 American comedy television series

• The Last Man on Planet Earth, a 1999 television movie
• Y: The Last Man, a science fiction comic book series
• Last Woman on Earth, 1960 science fiction film
• Last One on Earth, 1992 album
• The Last Man (disambiguation)