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TRPM4-IN-5

TRPM4-IN-5
Identifiers
  • 4-chloro-2-{[2-(2-chlorophenoxy)acetyl]amino}benzoic acid
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC15H11Cl2NO4
Molar mass340.16 g·mol−1
3D model (JSmol)
  • C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl
  • InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)
  • Key:CVQCJPCMPGKEDH-UHFFFAOYSA-N

TRPM4-IN-5 is a drug which acts as a moderately potent but highly selective blocker of the TRPM4 ion channel, with an IC50 of 1.5μM.[1] It is protective against glutamate mediated neuronal excitotoxicity.[2]

References

  1. ^ Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, et al. (June 2018). "Identification of potent and selective small molecule inhibitors of the cation channel TRPM4". British Journal of Pharmacology. 175 (12): 2504–2519. doi:10.1111/bph.14220. PMC 6002741. PMID 29579323.
  2. ^ Bianchi B, Smith PA, Abriel H (July 2018). "The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration". Molecular Brain. 11 (1): 41. doi:10.1186/s13041-018-0385-4. PMC 6042389. PMID 29996905.
Quelle: https://en.wikipedia.org/wiki/TRPM4-IN-5