Protein found in humans
Death receptor 4 (DR4 ), also known as TRAIL receptor 1 (TRAILR1 ) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A ), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis .[ 5] [ 6]
Function The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis.[ 7]
Studies with FADD-deficient mice suggested that FADD , a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[ 8]
Interactions TNFRSF10A has been shown to interact with DAP3 .[ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000104689 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022074 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL" . EMBO J . 16 (17): 5386–97. doi :10.1093/emboj/16.17.5386 . PMC 1170170 PMID 9311998 . ^ Pan G, O'Rourke K, Chinnaiyan AM , Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science . 276 (5309): 111–3. doi :10.1126/science.276.5309.111 . PMID 9082980 . S2CID 19984057 . ^ "Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a" .^ Kuang AA, Diehl GE, Zhang J, Winoto A (2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts" . J. Biol. Chem . 275 (33): 25065–8. doi :10.1074/jbc.C000284200 PMID 10862756 . ^ Miyazaki T, Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol . 2 (6): 493–500. doi :10.1038/88684 . ISSN 1529-2908 . PMID 11376335 . S2CID 6923467 .
Further reading
Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors" . Cell Res . 14 (5): 359–72. doi :10.1038/sj.cr.7290236 PMID 15538968 . Fleury S, Thibodeau J, Croteau G, et al. (1995). "HLA-DR polymorphism affects the interaction with CD4" . J. Exp. Med . 182 (3): 733–41. doi :10.1084/jem.182.3.733 . PMC 2192178 PMID 7650480 . MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL" . J. Biol. Chem . 272 (41): 25417–20. doi :10.1074/jbc.272.41.25417 PMID 9325248 . Schneider P, Bodmer JL, Thome M, et al. (1997). "Characterization of two receptors for TRAIL" (PDF) . FEBS Lett . 416 (3): 329–34. doi :10.1016/S0014-5793(97)01231-3 PMID 9373179 . S2CID 83145771 . Chaudhary PM, Eby M, Jasmin A, et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway" . Immunity . 7 (6): 821–30. doi :10.1016/S1074-7613(00)80400-8 PMID 9430227 . Schneider P, Thome M, Burns K, et al. (1998). "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB" . Immunity . 7 (6): 831–6. doi :10.1016/S1074-7613(00)80401-X PMID 9430228 . Diab BY, Lambert NC, L'Faqihi FE, et al. (1999). "Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis". Immunogenetics . 49 (1): 36–44. doi :10.1007/s002510050461 . PMID 9811967 . S2CID 22393348 . Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB" . J. Biol. Chem . 274 (29): 20127–32. doi :10.1074/jbc.274.29.20127 PMID 10400625 . Hymowitz SG, Christinger HW, Fuh G, et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5" . Mol. Cell . 4 (4): 563–71. doi :10.1016/S1097-2765(00)80207-5 PMID 10549288 . Gibson SB, Oyer R, Spalding AC, et al. (2000). "Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL" . Mol. Cell. Biol . 20 (1): 205–12. doi :10.1128/MCB.20.1.205-212.2000 . PMC 85076 PMID 10594023 . Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol . 2 (6): 493–500. doi :10.1038/88684 . PMID 11376335 . S2CID 6923467 . Trauzold A, Wermann H, Arlt A, et al. (2001). "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells" . Oncogene . 20 (31): 4258–69. doi :10.1038/sj.onc.1204559 PMID 11464292 . Dörr J, Bechmann I, Waiczies S, et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain" . J. Neurosci . 22 (4): RC209. doi :10.1523/JNEUROSCI.22-04-j0001.2002 PMC 6757573 PMID 11844843 . Koyama S, Koike N, Adachi S (2002). "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor". J. Cancer Res. Clin. Oncol . 128 (2): 73–9. doi :10.1007/s004320100292 . PMID 11862476 . S2CID 19509629 . Guan B, Yue P, Lotan R, Sun SY (2002). "Evidence that the human death receptor 4 is regulated by activator protein 1". Oncogene . 21 (20): 3121–9. doi :10.1038/sj.onc.1205430 . PMID 12082627 . S2CID 6726601 . Söderström TS, Poukkula M, Holmström TH, et al. (2002). "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8" . J. Immunol . 169 (6): 2851–60. doi :10.4049/jimmunol.169.6.2851 PMID 12218097 .
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Chemokine CSF
Interferon
IFNAR (α/β, I)
Agonists: Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1 , IFNB3 )Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b IFNGR (γ, II) IFNLR (λ, III)
See IL-28R (IFNLR) here instead.
Interleukin TGFβ TNF Others
