THP may refer to:

• Tamm–Horsfall protein (also known as uromodulin), a glycoprotein found in urine
• Tetrahydropalmatine, a plant alkaloid
• Tetrahydroprogesterone, any of four stereoisomer neurosteroid metabolites of progesterone with the word pregnanolone
• Tetrahydropyran, an organic chemical
• THP-1 cell line, a human cell line derived from a leukemia patient used in immunocytochemical analysis
• Trihexyphenidyl, an antiparkinsonian agent

• Tan Hiep Phat Beverage Group, a Vietnamese drink producer
• Tennessee Highway Patrol, a law enforcement agency in the US
• Texas Highway Patrol, a law enforcement agency in the US
• The Hunger Project, an American non-profit organization working to end food shortages around the world
• Thermal hydrolysis process, a sewage treatment method
• THP Orchestra, a 1970s Canadian disco band
• Tomlinson-Harashima precoding, a version of dirty paper coding, a mathematical technique to reduce the impact of interference in digital communications
• Trembling-hand perfection or trembling hand perfect equilibrium, a concept in game theory
• Turbo High Pressure, a variant of the Prince engine developed by BMW and PSA Peugeot Citroën