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TEAD4

TEAD4
Identifiers
AliasesTEAD4, EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B, TEA domain transcription factor 4
External IDsOMIM: 601714; MGI: 106907; HomoloGene: 74463; GeneCards: TEAD4; OMA:TEAD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7004

21679

Ensembl

ENSG00000197905

ENSMUSG00000030353

UniProt

Q15561

Q62296

RefSeq (mRNA)

NM_201443
NM_003213
NM_201441

NM_001080979
NM_011567

RefSeq (protein)

NP_003204
NP_958849
NP_958851

NP_001074448
NP_035697

Location (UCSC)Chr 12: 2.96 – 3.04 MbChr 6: 128.2 – 128.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.[5][6][7]

Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. TEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.[7] Gene ablation experiments in mice (i.e. knockout mice) showed that TEAD4 is essential for the formation of blastocysts during preimplantation embryo development.[9][10] Although it was originally hypothesized to be essential for specification of trophectoderm lineage, it was later shown that functional trophectoderm can be produced leading to formation of blastocysts under in vitro conditions that suppress oxidative stress.[11] Transcriptional coregulators, such as WWTR1 (TAZ) bind to members in this transcription factor family.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197905 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030353 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (January 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. hdl:2268/13836. PMID 9889009.
  6. ^ Stewart AF, Richard CW, Suzow J, Stephan D, Weremowicz S, Morton CC, Adra CN (October 1996). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family". Genomics. 37 (1): 68–76. doi:10.1006/geno.1996.0522. PMID 8921372.
  7. ^ a b "Entrez Gene: TEAD4 TEA domain family member 4".
  8. ^ Bürglin TR (July 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–2. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. S2CID 2819591.
  9. ^ Yagi R, Kohn MJ, Karavanova I, Kaneko KJ, Vullhorst D, DePamphilis ML, Buonanno A (November 2007). "Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development". Development. 134 (21): 3827–36. doi:10.1242/dev.010223. PMID 17913785.
  10. ^ Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H (2008). "Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos". Mechanisms of Development. 125 (3–4): 270–83. doi:10.1016/j.mod.2007.11.002. PMID 18083014. S2CID 13898262.
  11. ^ Kaneko KJ, DePamphilis ML (September 2013). "TEAD4 establishes the energy homeostasis essential for blastocoel formation". Development. 140 (17): 3680–90. doi:10.1242/dev.093799. PMC 3742148. PMID 23903192.

Further reading

Quelle: https://en.wikipedia.org/wiki/TEAD4