Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3gene.[5][6][7]
Function
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. Transcriptional coregulators, such as WWTR1 (TAZ) bind to these transcription factors. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.[9] Translation of this protein is initiated at a non-AUG (AUA) start codon.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. hdl:2268/13836. PMID9889009.
Vaudin P, Delanoue R, Davidson I, Silber J, Zider A (Nov 1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation". Development. 126 (21): 4807–16. doi:10.1242/dev.126.21.4807. PMID10518497.
