Santee is a city located in San Diego County, California. As of the 2000 census, the city had a total population of 52,975.

A middle-class suburb of San Diego.

The majority of Santee is Republican, but over the years the city has become more mixed and other parties have become more common. This may do to the booming housing industry, some properties gaining over $100,000 in equity in one year.

On March 5, 2001, a boy named Charles Andrew Williams opened fire in a boys' bathroom at Santana High School in Santee. Two students died and thirteen students were wounded. He plead guilty and was sentenced to 50 years to life in prison.

A brand new shopping and dining center, simply named the Santee Town Center, opened in 2004 on the site of the San Diego Trolley stop. A new YMCA also opened nearby.

In early 2005, Santee held a referendum to severely restrict the development of new homes on Fanita Ranch. The proposition was soundly defeated.

As of the censusTemplate:GR of 2000, there were 52,975 people, 18,470 households, and 14,018 families residing in the city. The population density was 1,273.6/km² (3,298.7/mi²). There were 18,833 housing units at an average density of 452.8/km² (1,172.7/mi²). The racial makeup of the city was 86.70% White, 1.48% African American, 0.81% Native American, 2.55% Asian, 0.41% Pacific Islander, 4.03% from other races, and 4.03% from two or more races. 11.36% of the population were Hispanic or Latino of any race.

There were 18,470 households out of which 40.9% had children under the age of 18 living with them, 57.7% were married couples living together, 13.0% had a female householder with no husband present, and 24.1% were non-families. 18.2% of all households were made up of individuals and 6.9% had someone living alone who was 65 years of age or older. The average household size was 2.81 and the average family size was 3.19.

In the city the population was spread out with 28.2% under the age of 18, 8.4% from 18 to 24, 32.9% from 25 to 44, 21.6% from 45 to 64, and 8.9% who were 65 years of age or older. The median age was 35 years. For every 100 females there were 93.2 males. For every 100 females age 18 and over, there were 89.1 males.

The median income for a household in the city was $53,624, and the median income for a family was $57,874. Males had a median income of $41,347 versus $30,187 for females. The per capita income for the city was $21,311. 5.4% of the population and 3.8% of families were below the poverty line. 6.5% of those under the age of 18 and 3.4% of those 65 and older were living below the poverty line.

According to estimates by the San Diego Association of Governments, the median household income of Santee in 2005 was $73,846 (not adjusted for inflation). When adjusted for inflation (1999 dollars; comparable to Census data above), the median household income was $59,965.

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