The Dene are a group of First Nations that live in the Arctic regions of Canada. The Dene speak Athabaskan languages of the Na-Dené language family, and were the first people to settle in what is now the Northwest Territories.

The Dene include five main groups:

• Chipewyan (Denesuline), living east of Great Slave Lake;
• Tli Cho (Dogrib), living between Great Slave and Great Bear Lakes;
• Yellowknives (T'atsaot'ine), formerly living north of Great Slave Lake, and now absorbed into the Chipewyan;
• Slavey (Deh Gah Got'ine), living along the Mackenzie River (Deh Cho) southwest of Great Slave Lake;
• Sahtu (Sahtu' T'ine), including the Locheux, Nahanni, and Bear Lake peoples, in the southwestern NWT.

Well-known Dene include Ethel Blondin-Andrew, MP for Western Arctic (the federal riding that comprises the Northwest Territories). The Canadian television series North of 60 took place among a Dene community.

Behchoko, Northwest Territories is the largest Dene community in Canada.

• Dene Nation
• People of the Deh Cho