Simone may refer to:

• Simone (given name), a feminine (or Italian masculine) given name of Hebrew origin
• Simone (surname), an Italian surname
• People known mononymously as Simone include:
  • Simone Bittencourt de Oliveira (born 1949), Brazilian singer
  • Simone Egeriis (born 1992), Danish pop singer
  • Simone Philip Kamel (born 1966), Egyptian singer
  • Simone Mendes (born 1984), Brazilian singer-songwriter
  • Lisa Simone (born 1962), American singer, composer and actress
  • Nina Simone (1933–2003), American singer, songwriter, musician, arranger, and civil rights activist

• Simone (1918 film), a French silent drama film
• Simone (1926 film), a French silent drama film
• Simone (2002 film), a science-fiction drama film

• Tropical Storm Simone (disambiguation), two tropical cyclones in the Eastern Pacific Ocean
  • 1961's Tropical Storm Simone – a continuation of Atlantic Hurricane Hattie
  • Tropical Storm Simone (1968)
• "Simone", a song by Goldfrapp from Tales of Us
• Simone (character), a fictional character in the ABC Family show The Nine Lives of Chloe King
• Simone (The Marvelous Mrs. Maisel), an episode from season 2 of The Marvelous Mrs. Maisel

• Simon (disambiguation)