Seleucus may refer to:

• Seleucus I Nicator (Satrap 311–305 BC, King 305 BC–281 BC), son of Antiochus and founder of the Seleucid Empire
• Seleucus II Callinicus (246–225 BC)
• Seleucus III Ceraunus (or Soter) (225–223 BC)
• Seleucus IV Philopator (187–175 BC)
• Seleucus V Philometor (126/125 BC)
• Seleucus VI Epiphanes Nicator (96–95 BC)
• Seleucus VII Kybiosaktes or Philometor (70s BC–60s BC?)
• Seleucus, probable name of the father of Antiochus (father of Seleucus I Nicator)
• Seleucus, a son of Antiochus I Soter and grandson to Seleucus I
• Seleucus, one of the sons of Antiochus VII Sidetes and Cleopatra Thea
• Seleucus (commandant), in 30 BC commandant of the eastern Egyptian border-fortress Pelusium

• Seleucus, son of Bithys, Ptolemaic governor of Cyprus (c.145-130 BC),
• Seleucus of Alexandria, a grammarian and sophist,
• Seleucus of Seleucia, an astronomer,
• Seleucus (son of Ablabius), a rhetorician and friend of Julian the Apostate,
• Seleucus (Theodosian Praetorian prefect), Praetorian prefect of the Theodosian dynasty,
• Seleucus (Roman usurper), a Roman usurper.

• Seleucus (crater), a crater on Earth's moon
• 3288 Seleucus, an asteroid

• Seleucia (disambiguation)
• Seleucid Empire