Santa Susana may refer to:

• Susanna (disciple), disciple of Jesus according to the gospel of Luke;
• Susanna of Rome, martyred in 295.

Santa Susana or Santa Susanna may also refer to several places:

• Santa Susana, California, a census-designated place in Ventura County
• Santa Susana Mountains in southern California.
• Santa Susana Mountains, a mountain range northwest of Los Angeles
• Santa Susana Pass, running through the Santa Susana Mountains
• Santa Susana Field Laboratory, near Los Angeles, a test facility for rockets and (formerly) nuclear reactors
• Santa Susanna, Rome, a church on the Quirinal in Rome
• Santa Susanna, Spain, a small town on the Costa del Maresme of Spain