San Marcos, Antioquia
Municipality and town
Country	Colombia
Department	Antioquia Department
Time zone	UTC-5 (Colombia Standard Time)

San Marcos is a town in Antioquia department in Colombia. It is approximately 175 miles (282 km) north of Medellín, in the heart of Colombia's coffee-growing region.

San Marcos is located at 8°38′N 75°10′W / 8.633°N 75.167°W / 8.633; -75.167. The symbol for its airport is SRS.