Radcliffe is a surname. Notable people with the name include:

• Alex Radcliffe (1905–1983), US baseball player
• Ann Radcliffe (1764–1823), English novelist
• Aubrey Radcliffe (1933–2009), US academic
• Bill Radcliffe (1917–1984), Manx teacher and Manx-Gaelic language advocate
• Charles Radcliffe (1941–2021), English magazine editor
• Cyril Radcliffe, 1st Viscount Radcliffe (1899–1977), British lawyer
• Daniel Radcliffe (born 1989), English actor
• Egremont Radcliffe (died 1578), English rebel
• Eric Radcliffe, British recording engineer and music producer
• George Radcliffe (politician) (1593–1657), English politician
• George L. P. Radcliffe (1877–1974), US Senator from Maryland
• Jacob Radcliff (1764–1844), US politician
• John Radcliffe, disambiguation
• Mark Radcliffe, disambiguation
• Mary Radcliffe, disambiguation
• Melva Radcliffe (1901–2012), supercentenarian from in New Jersey
• Mike Radcliffe (born 1944), Canadian politician
• Paula Radcliffe (born 1973), English athlete
• Percy Radcliffe (1916–1991), Manx politician, member of the Legislative Council of the Isle of Man
• Richard Radcliffe (died 1660), English politician who sat in the House of Commons in 1656
• Rip Radcliff (1906–1962), American baseball player
• Rosemary Radcliffe (born 1949), Canadian actress
• Ted Radcliffe (1902–2005), US baseball player
• Timothy Radcliffe (born 1945), former Master of the Order of Preachers (Dominicans) 1992–2001