Enzyme found in humans
RPS6KA3 Identifiers Aliases RPS6KA3 External IDs OMIM : 300075 ; MGI : 104557 ; HomoloGene : 37940 ; GeneCards : RPS6KA3 ; OMA :RPS6KA3 - orthologs Wikidata
protein S6 kinase, 90kDa, polypeptide 3 , also s RPS6KA3 , is an enzyme that in humans is encoded by the RPS6KA3 gene .[ 5] [ 6]
Function This gene encodes a member of the RSK (ribosomal S6 kinase ) family of serine/threonine kinases . This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway . The activity of this protein has been implicated in controlling cell growth and differentiation.[ 5]
Clinical significance Mutations in this gene have been associated with Coffin–Lowry syndrome (CLS).[ 7]
Interactions RPS6KA3 has been shown to interact with CREB-binding protein ,[ 8] MAPK1 [ 9] [ 10] PEA15 .[ 11]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000177189 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031309 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3" .^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (February 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression" . The American Journal of Physiology . 266 (2 Pt 1): C351–9. doi :10.1152/ajpcell.1994.266.2.C351 . PMID 8141249 . ^ Jacquot S, Zeniou M, Touraine R, Hanauer A (January 2002). "X-linked Coffin-Lowry syndrome (CLS, MIM 303600, RPS6KA3 gene, protein product known under various names: pp90(rsk2), RSK2, ISPK, MAPKAP1)" . European Journal of Human Genetics . 10 (1): 2–5. doi :10.1038/sj.ejhg.5200738 PMID 11896450 . ^ Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P (October 2001). "Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities" . Molecular and Cellular Biology . 21 (20): 7089–96. doi :10.1128/MCB.21.20.7089-7096.2001 . PMC 99884 PMID 11564891 . ^ Zhao Y, Bjorbaek C, Moller DE (November 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases" . The Journal of Biological Chemistry . 271 (47): 29773–9. doi :10.1074/jbc.271.47.29773 PMID 8939914 . ^ Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (January 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo" . The Journal of Biological Chemistry . 274 (5): 2893–8. doi :10.1074/jbc.274.5.2893 PMID 9915826 . ^ Vaidyanathan H, Ramos JW (August 2003). "RSK2 activity is regulated by its interaction with PEA-15" . The Journal of Biological Chemistry . 278 (34): 32367–72. doi :10.1074/jbc.M303988200 PMID 12796492 .
Further reading
Omary MB, Baxter GT, Chou CF, Riopel CL, Lin WY, Strulovici B (May 1992). "PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18" . The Journal of Cell Biology . 117 (3): 583–93. doi :10.1083/jcb.117.3.583 . PMC 2289443 PMID 1374067 . Ku NO, Omary MB (October 1994). "Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization" . The Journal of Cell Biology . 127 (1): 161–71. doi :10.1083/jcb.127.1.161 . PMC 2120194 PMID 7523419 . Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174. PMID 7566098 . Zhao Y, Bjørbaek C, Weremowicz S, Morton CC, Moller DE (August 1995). "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation" . Molecular and Cellular Biology . 15 (8): 4353–63. doi :10.1128/MCB.15.8.4353 . PMC 230675 PMID 7623830 . Bjørbaek C, Vik TA, Echwald SM, Yang PY, Vestergaard H, Wang JP, Webb GC, Richmond K, Hansen T, Erikson RL (January 1995). "Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients". Diabetes . 44 (1): 90–7. doi :10.2337/diabetes.44.1.90 . PMID 7813820 . Donnelly AJ, Choo KH, Kozman HM, Gedeon AK, Danks DM, Mulley JC (July 1994). "Regional localisation of a non-specific X-linked mental retardation gene (MRX19) to Xp22". American Journal of Medical Genetics . 51 (4): 581–5. doi :10.1002/ajmg.1320510457 . PMID 7943043 . Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (February 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". The American Journal of Physiology . 266 (2 Pt 1): C351–9. doi :10.1152/ajpcell.1994.266.2.C351 . PMID 8141249 . Xing J, Ginty DD, Greenberg ME (August 1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science . 273 (5277): 959–63. Bibcode :1996Sci...273..959X . doi :10.1126/science.273.5277.959 . PMID 8688081 . S2CID 22226803 . Trivier E, De Cesare D, Jacquot S, Pannetier S, Zackai E, Young I, Mandel JL, Sassone-Corsi P, Hanauer A (December 1996). "Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome". Nature . 384 (6609): 567–70. Bibcode :1996Natur.384..567T . doi :10.1038/384567a0 . PMID 8955270 . S2CID 4242547 . Paudel HK (November 1997). "Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro" . The Journal of Biological Chemistry . 272 (45): 28328–34. doi :10.1074/jbc.272.45.28328 PMID 9353289 . Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA (April 1998). "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167" . Molecular and Cellular Biology . 18 (4): 1978–84. doi :10.1128/mcb.18.4.1978 . PMC 121427 PMID 9528769 . Zheng-Fischhöfer Q, Biernat J, Mandelkow EM, Illenberger S, Godemann R, Mandelkow E (March 1998). "Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation" . European Journal of Biochemistry . 252 (3): 542–52. doi :10.1046/j.1432-1327.1998.2520542.x PMID 9546672 . Deak M, Clifton AD, Lucocq LM, Alessi DR (August 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . The EMBO Journal . 17 (15): 4426–41. doi :10.1093/emboj/17.15.4426 . PMC 1170775 PMID 9687510 . Du K, Montminy M (December 1998). "CREB is a regulatory target for the protein kinase Akt/PKB" . The Journal of Biological Chemistry . 273 (49): 32377–9. doi :10.1074/jbc.273.49.32377 PMID 9829964 . Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH (December 1998). "New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry" . Journal of Neurochemistry . 71 (6): 2465–76. doi :10.1046/j.1471-4159.1998.71062465.x PMID 9832145 . Jacquot S, Merienne K, De Cesare D, Pannetier S, Mandel JL, Sassone-Corsi P, Hanauer A (December 1998). "Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations" . American Journal of Human Genetics . 63 (6): 1631–40. doi :10.1086/302153 . PMC 1377634 PMID 9837815 . Jacquot S, Merienne K, Pannetier S, Blumenfeld S, Schinzel A, Hanauer A (1999). "Germline mosaicism in Coffin-Lowry syndrome" . European Journal of Human Genetics . 6 (6): 578–82. doi :10.1038/sj.ejhg.5200230 PMID 9887375 . Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (January 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo" . The Journal of Biological Chemistry . 274 (5): 2893–8. doi :10.1074/jbc.274.5.2893 PMID 9915826 . Abidi F, Jacquot S, Lassiter C, Trivier E, Hanauer A, Schwartz CE (January 1999). "Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS)" . European Journal of Human Genetics . 7 (1): 20–6. doi :10.1038/sj.ejhg.5200231 PMID 10094187 . Merienne K, Jacquot S, Pannetier S, Zeniou M, Bankier A, Gecz J, Mandel JL, Mulley J, Sassone-Corsi P, Hanauer A (May 1999). "A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation". Nature Genetics . 22 (1): 13–4. doi :10.1038/8719 . PMID 10319851 . S2CID 30949315 .
External links
Activity Regulation Classification Kinetics Types
