ROCK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L6Q, 4WOT
Identifiers
Aliases	ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
External IDs	OMIM: 604002; MGI: 107926; HomoloGene: 21010; GeneCards: ROCK2; OMA:ROCK2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 11,179,759 bp[1] End 11,348,330 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 16,894,895 bp[2] End 16,987,823 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Top expressed in More reference expression data BioGPS n/a
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9475 19878 Ensembl ENSG00000134318 ENSMUSG00000020580 UniProt O75116 P70336 RefSeq (mRNA) NM_004850 NM_001321643 NM_009072 RefSeq (protein) NP_001308572 NP_004841 NP_033098 Location (UCSC) Chr 2: 11.18 – 11.35 Mb Chr 12: 16.89 – 16.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. ^[5]Fasudil is an inhibitor of ROCK protein.

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

• Overview of all the structural information available in the PDB for UniProt: O75116 (Human Rho-associated protein kinase 2 (ROCK2)) at the PDBe-KB.