Protein-coding gene in the species Homo sapiens
Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene .[ 5]
Function This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein , which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.[ 6]
Interactions RBBP7 has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000102054 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031353 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Qian YW, Lee EY (Dec 1995). "Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast" . J Biol Chem . 270 (43): 25507–25513. doi :10.1074/jbc.270.43.25507 PMID 7503932 . ^ "Entrez Gene: RBBP7 retinoblastoma binding protein 7" .^ a b Yarden RI, Brody LC (April 1999). "BRCA1 interacts with components of the histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 96 (9): 4983–8. Bibcode :1999PNAS...96.4983Y . doi :10.1073/pnas.96.9.4983 PMC 21803 PMID 10220405 . ^ Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY (June 2001). "Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1". Biochem. Biophys. Res. Commun . 284 (2): 507–14. doi :10.1006/bbrc.2001.5003 . PMID 11394910 . ^ Yarden RI, Brody LC (2001). "Identification of proteins that interact with BRCA1 by Far-Western library screening" . J. Cell. Biochem . 83 (4): 521–31. doi :10.1002/jcb.1257 . PMID 11746496 . S2CID 29703139 . ^ Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (January 2002). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex" . Mol. Cell. Biol . 22 (2): 536–46. doi :10.1128/mcb.22.2.536-546.2002 . PMC 139742 PMID 11756549 . ^ a b Yao YL, Yang WM (October 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity" . J. Biol. Chem . 278 (43): 42560–8. doi :10.1074/jbc.M302955200 PMID 12920132 . ^ Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (September 1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nat. Genet . 23 (1): 58–61. doi :10.1038/12659 . hdl :1842/684 PMID 10471499 . S2CID 6147725 . ^ a b c Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation" . Genes Dev . 13 (15): 1924–35. doi :10.1101/gad.13.15.1924 . PMC 316920 PMID 10444591 . ^ Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex" . Cell . 89 (3): 357–64. doi :10.1016/s0092-8674(00)80216-0 PMID 9150135 . ^ a b Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (June 1998). "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex" . Mol. Cell . 1 (7): 1021–31. doi :10.1016/s1097-2765(00)80102-1 PMID 9651585 . ^ a b Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)" . Mol. Cell. Biol . 22 (3): 835–48. doi :10.1128/mcb.22.3.835-848.2002 . PMC 133546 PMID 11784859 .
Further reading
Huang S, Lee WH, Lee EY (1991). "A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product". Nature . 350 (6314): 160–162. Bibcode :1991Natur.350..160H . doi :10.1038/350160a0 . PMID 2005966 . S2CID 4345233 . Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex" . Cell . 89 (3): 357–364. doi :10.1016/S0092-8674(00)80216-0 PMID 9150135 . Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998). "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase" . Curr. Biol . 8 (2): 96–108. Bibcode :1998CBio....8...96V . doi :10.1016/S0960-9822(98)70040-5 PMID 9427644 . S2CID 201273 . Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (1998). "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex" . Mol. Cell . 1 (7): 1021–1031. doi :10.1016/S1097-2765(00)80102-1 PMID 9651585 . Guan LS, Rauchman M, Wang ZY (1998). "Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition" . J. Biol. Chem . 273 (42): 27047–27050. doi :10.1074/jbc.273.42.27047 PMID 9765217 . Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities" . Cell . 95 (2): 279–289. doi :10.1016/S0092-8674(00)81758-4 PMID 9790534 . S2CID 18786866 . Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature . 395 (6705): 917–921. Bibcode :1998Natur.395..917T . doi :10.1038/27699 . PMID 9804427 . S2CID 4355885 . Yarden RI, Brody LC (1999). "BRCA1 interacts with components of the histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 96 (9): 4983–4988. Bibcode :1999PNAS...96.4983Y . doi :10.1073/pnas.96.9.4983 PMC 21803 PMID 10220405 . Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation" . Genes Dev . 13 (15): 1924–1935. doi :10.1101/gad.13.15.1924 . PMC 316920 PMID 10444591 . Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation". Nat. Genet . 23 (1): 62–66. doi :10.1038/12664 . PMID 10471500 . S2CID 52868103 . Zhang Q, Vo N, Goodman RH (2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB" . Mol. Cell. Biol . 20 (14): 4970–4978. doi :10.1128/MCB.20.14.4970-4978.2000 . PMC 85947 PMID 10866654 . Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1" . J. Biol. Chem . 276 (9): 6817–6824. doi :10.1074/jbc.M007372200 PMID 11102443 . Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J (2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex" . J. Biol. Chem . 276 (12): 8734–8739. doi :10.1074/jbc.M007664200 PMID 11118440 . Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY (2001). "Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1". Biochem. Biophys. Res. Commun . 284 (2): 507–514. doi :10.1006/bbrc.2001.5003 . PMID 11394910 . Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening" . J. Cell. Biochem . 83 (4): 521–531. doi :10.1002/jcb.1257 . PMID 11746496 . S2CID 29703139 . Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)" . Mol. Cell. Biol . 22 (3): 835–848. doi :10.1128/MCB.22.3.835-848.2002 . PMC 133546 PMID 11784859 . Vaute O, Nicolas E, Vandel L, Trouche D (2002). "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases" . Nucleic Acids Res . 30 (2): 475–481. doi :10.1093/nar/30.2.475 . PMC 99834 PMID 11788710 . Saito M, Ishikawa F (2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2" . J. Biol. Chem . 277 (38): 35434–35439. doi :10.1074/jbc.M203455200 PMID 12124384 . Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D (2002). "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein" . Genes Dev . 16 (22): 2893–2905. doi :10.1101/gad.1035902 . PMC 187479 PMID 12435631 .
