The Premios 40 Principales for Best America Song is an honor presented annually at the Los 40 Principaless, a ceremony that recognizes excellence, creates a greater awareness of cultural diversity and contributions of Latino artists in the international scene.

This is a list of the Los Premios 40 Principales winners and nominees for Song of the Year.

Year	Winner	Other nominees
2012	Jesse & Joy — "¡Corre!"	Cali & El Dandee — "Yo Te Esperaré" Alejandro Sanz — "No Me Compares" Daddy Yankee — "Lovumba" J Alvarez — "La Pregunta"

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