Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4gene.[5][6]
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.[6]
Park KW, Lee EJ, Lee S, Lee JE, Choi E, Kim BJ, Hwang R, Park KA, Baik J (2001). "Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG". Gene. 257 (1): 45–55. doi:10.1016/S0378-1119(00)00351-6. PMID11054567.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID16169070. S2CID8235923.
External links
Overview of all the structural information available in the PDB for UniProt: P29074 (Human Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)) at the PDBe-KB.
PDB gallery
2cs5: Solution structure of PDZ domain of Protein tyrosine phosphatase, non-receptor type 4
2i75: Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4)
