Protein-coding gene in the species Homo sapiens
Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene .[ 5] [ 6] [ 7]
References
Further reading
Honda A, Nogami M, Yokozeki T, et al. (1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation" . Cell . 99 (5): 521– 32. doi :10.1016/S0092-8674(00)81540-8 PMID 10589680 . S2CID 10031591 . Jones DH, Morris JB, Morgan CP, et al. (2000). "Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment" . J. Biol. Chem . 275 (18): 13962– 6. doi :10.1074/jbc.C901019199 PMID 10747863 . Divecha N, Roefs M, Halstead JR, et al. (2000). "Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity" . EMBO J . 19 (20): 5440– 9. doi :10.1093/emboj/19.20.5440 . PMC 314009 PMID 11032811 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Doughman RL, Firestone AJ, Wojtasiak ML, et al. (2003). "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling" . J. Biol. Chem . 278 (25): 23036– 45. doi :10.1074/jbc.M211397200 PMID 12682053 . Chang JD, Field SJ, Rameh LE, et al. (2004). "Identification and characterization of a phosphoinositide phosphate kinase homolog" . J. Biol. Chem . 279 (12): 11672– 9. doi :10.1074/jbc.M309721200 PMID 14701839 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Kisseleva M, Feng Y, Ward M, et al. (2005). "The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha" . Mol. Cell. Biol . 25 (10): 3956– 66. doi :10.1128/MCB.25.10.3956-3966.2005 . PMC 1087706 PMID 15870270 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315– 21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Halstead JR, van Rheenen J, Snel MH, et al. (2006). "A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis" . Curr. Biol . 16 (18): 1850– 6. doi :10.1016/j.cub.2006.07.066 PMID 16979564 . S2CID 15282445 . Im YJ, Perera IY, Brglez I, et al. (2007). "Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum" . Plant Cell . 19 (5): 1603– 16. doi :10.1105/tpc.107.051367 . PMC 1913725 PMID 17496116 .
