Protein-coding gene in the species Homo sapiens
For the anti-inflammatory ointment called Picalm, see
Piketoprofen .
Phosphatidylinositol binding clathrin assembly protein , also known as PICALM , is a protein which in humans is encoded by the PICALM gene .[ 5]
Interactions PICALM has been shown to interact with CLTC .[ 6]
Clinical significance In humans, certain alleles of this gene have been statistically associated with an increased risk of developing late-onset Alzheimer's disease .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000073921 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039361 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: PICALM phosphatidylinositol binding clathrin assembly protein" .^ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic" (PDF) . Mol. Biol. Cell . 10 (8). UNITED STATES: 2687– 702. doi :10.1091/mbc.10.8.2687 . ISSN 1059-1524 . PMC 25500 PMID 10436022 . ^ Harold D, Abraham R, Hollingworth P, et al. (September 2009). "Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease" . Nat. Genet . 41 (10): 1088– 93. doi :10.1038/ng.440 . PMC 2845877 PMID 19734902 .
Further reading
Ron D, Habener JF (1992). "CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription" . Genes Dev . 6 (3): 439– 53. doi :10.1101/gad.6.3.439 PMID 1547942 . Dreyling MH, Martinez-Climent JA, Zheng M, et al. (1996). "The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family" . Proc. Natl. Acad. Sci. U.S.A . 93 (10): 4804– 9. Bibcode :1996PNAS...93.4804D . doi :10.1073/pnas.93.10.4804 PMC 39360 PMID 8643484 . Silliman CC, McGavran L, Wei Q, et al. (1998). "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides" . Leukemia . 12 (9): 1404– 10. doi :10.1038/sj.leu.2401109 PMID 9737689 . Tebar F, Bohlander SK, Sorkin A (1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic" . Mol. Biol. Cell . 10 (8): 2687– 702. doi :10.1091/mbc.10.8.2687 . PMC 25500 PMID 10436022 . Kim JA, Kim SR, Jung YK, et al. (2000). "Properties of GST-CALM expressed in E. coli" . Exp. Mol. Med . 32 (2): 93– 9. doi :10.1038/emm.2000.17 PMID 10926122 . S2CID 9913485 . Wechsler DS, Engstrom LD, Alexander BM, et al. (2003). "A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein" (PDF) . Genes Chromosomes Cancer . 36 (1): 26– 36. doi :10.1002/gcc.10136 . hdl :2027.42/35133 PMID 12461747 . S2CID 6463540 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707– 16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Park SY, Ha BG, Choi GH, et al. (2004). "EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment". Biochemistry . 43 (23): 7552– 62. doi :10.1021/bi049970f . PMID 15182197 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Meyerholz A, Hinrichsen L, Groos S, et al. (2006). "Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation" . Traffic . 6 (12): 1225– 34. doi :10.1111/j.1600-0854.2005.00355.x PMID 16262731 . S2CID 8040699 . Archangelo LF, Gläsner J, Krause A, Bohlander SK (2006). "The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10" . Oncogene . 25 (29): 4099– 109. doi :10.1038/sj.onc.1209438 PMID 16491119 . Deshpande AJ, Cusan M, Rawat VP, et al. (2007). "Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia" . Cancer Cell . 10 (5): 363– 74. doi :10.1016/j.ccr.2006.08.023 PMID 17097559 . Abdelhaleem M, Beimnet K, Kirby-Allen M, et al. (2007). "High incidence of CALM-AF10 fusion and the identification of a novel fusion transcript in acute megakaryoblastic leukemia in children without Down's syndrome" . Leukemia . 21 (2): 352– 3. doi :10.1038/sj.leu.2404503 PMID 17170719 . Ashihara E, Nakamura S, Inaba T, et al. (2007). "A novel AF10-CALM fusion transcript in gamma/delta-T cell type lymphoblastic lymphoma" . Am. J. Hematol . 82 (9): 859– 60. doi :10.1002/ajh.21021 PMID 17597474 . S2CID 72275219 . Caudell D, Zhang Z, Chung YJ, Aplan PD (2007). "Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice" . Cancer Res . 67 (17): 8022– 31. doi :10.1158/0008-5472.CAN-06-3749 . PMC 1986634 PMID 17804713 .
PDB gallery
1hf8 : CALM-N N-TERMINAL DOMAIN OF CLATHRIN ASSEMBLY LYMPHOID MYELOID LEUKAEMIA PROTEIN
1hfa : CALM-N N-TERMINAL DOMAIN OF CLATHRIN ASSEMBLY LYMPHOID MYELOID LEUKAEMIA PROTEIN, PI(4,5)P2 COMPLEX
1hg2 : CALM-N N-TERMINAL DOMAIN OF CLATHRIN ASSEMBLY LYMPHOID MYELOID LEUKAEMIA PROTEIN, INOSITOL(4,5)P2 COMPLEX
1hg5 : CALM-N N-TERMINAL DOMAIN OF CLATHRIN ASSEMBLY LYMPHOID MYELOID LEUKAEMIA PROTEIN, INOSITOL(1,2,3,4,5,6)P6 COMPLEX
