One on One may refer to:

• One on One (1977 film), a 1977 movie starring Robby Benson and Annette O'Toole
  • One on One (soundtrack), the soundtrack album from the film
• One on One (2014 film), a 2014 South Korean film

• "One on One", Alice (American) season 9, episode 14 (1985)
• "One on One", Betas episode 4 (2013)
• "One on One", Beverly Hills, 90210 season 1, episode 5 (1990)
• "One on One", Brothers (1984) season 4, episode 17 (1987)
• "One on One", Hangin' with Mr. Cooper season 5, episode 7 (1997)
• "One on One", High Tide season 2, episode 4 (1995)
• "One-on-One", Joanie Loves Chachi season 2, episode 3 (1982)
• "One on One", Love, Inc. episode 9 (2005)
• "One on One", My Secret Identity season 1, episode 16 (1989)
• "One on One", Sky Commanders episode 6 (1987)
• "One on One", SilverHawks episode 26 (1986)
• "One on One", Sister Wives season 16, episodes 11–13 (2022)
• "One on One", Sister Wives season 17, episodes 15–17 (2022–2023)
• "One on One", Sister Wives season 18, episodes 15–17 (2023)
• "One on One", Sparks season 1, episode 9 (1996)
• "One on One", The Clash season 4, episode 2 (2021)
• "One-on-One", The Crossover episode 3 (2023)
• "One on One", Time Trax season 1, episode 22 (1993)
• "One on One", Wiseguy season 1, episode 6 (1987)

• Mansbridge One on One, weekly TV program on CBC Television
• One on One (American TV series), a 2000s American sitcom
• One on One (Israeli TV series), a 2020 Israeli TV drama series
• One on One with John Tesh, a 1991-92 American daytime talk show hosted by John Tesh
• One on One with Steve Adubato, an American television talk show
• Riz Khan One on One, a former programme on Al Jazeera English

• One on One, by Shelly Manne and Russ Freeman, Atlas 1982
• One on One (Bob James and Earl Klugh album)
• One on One (Cheap Trick album)
• One on One (Mira Calix album)
• One on One (Randy Owen album)
• One on One (Stéphane Grappelli and McCoy Tyner album)
• One on One (Steve Camp album)
• One on One (Yazz album)
• One on One (One Songwriter, One Instrument), a Spiritone Records compilation album including a song by Ralston Bowles
• 1 on 1 (Rupee album), Rupee album 2004

• "One on One" (song), a song by Hall & Oates

• One on One (tour), a 2016-2017 concert world tour by Paul McCartney

• One on One (novel), a novel by Tabitha King
• One on One, an interview series on the SourceFed YouTube channel
• One on One: Dr. J vs. Larry Bird, a computer game
  • Jordan vs. Bird: One on One, a computer game and sequel to "One on One: Dr. J vs. Larry Bird"
• One on One, a game for PlayStation
• One on One with Igan, a Filipino radio show

• One-on-one (basketball), basketball game between two players

• One on one tackle, a play in rugby league football
• One-to-one (disambiguation)
• Personal (disambiguation)
• Professional wrestling match types#Variations of singles matches, often referred to as a one on one match