ONECUT1

ONECUT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S7E
Identifiers
Aliases	ONECUT1, HNF-6, HNF6, HNF6A, one cut homeobox 1
External IDs	OMIM: 604164; MGI: 1196423; HomoloGene: 3309; GeneCards: ONECUT1; OMA:ONECUT1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	52,791,078 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	74,799,063 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	3175
	15379
	ENSG00000169856
	ENSMUSG00000043013
	Q9UBC0
	O08755
	NM_004498
	NM_008262
	NP_004489
	NP_032288
	Wikidata
View/Edit Human	View/Edit Mouse

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. ^[5]

Function

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169856 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043013 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: One cut homeobox 1". Retrieved 2016-04-13.