O'Connell is a noble surname of Irish origin.^[1] It is an anglicisation of the Irish Ó Conaill (meaning "descendant of Conall").^[1] The personal name Conall is composed of the elements con (from cú meaning "hound") and gal (meaning "valour").^[1] The O'Connell family were a noted clan of Derrynane, Munster.

• Aaron D. O'Connell (born 1981), American experimental quantum physicist, creator of the world's first quantum machine
• Aaron O'Connell (born 1986), American model and actor
• Aidan O'Connell (born 1998), American football player
• Anthony O'Connell (1938–2012), American Catholic bishop
• Arthur O'Connell (1908–1981), American actor
• Bill O'Connell (born 1957), American photographer
• Billie Eilish O'Connell, known as Billie Eilish (born 2001), American singer and songwriter
• Beverly Reid O'Connell (1965–2017), American judge
• Carlos O'Connell (born 1963), Irish decathlete
• Charlie O'Connell (disambiguation), multiple people
• Christian O'Connell (born 1973), English radio DJ
• Conall O'Connell, senior Australian public servant
• Dáithí Ó Conaill (David O'Connell) (1938–1991), Irish republican
• Daniel O'Connell (1775–1847), Irish politician
• Daniel P. O'Connell (1885–1977), American politician from New York
• David O'Connell (disambiguation), multiple people
• Denis J. O'Connell (1849–1927), American Catholic bishop
• Eileen O'Connell (Irish writer) (c.1743–c.1800), Irish poet
• Eileen O'Connell (politician) (1947–2000), Canadian politician, member of the Nova Scotia House of Assembly
• Finneas O'Connell (born 1997), American actor and musician
• Frédérique Émilie Auguste O'Connell (1823–1885) German–French painter
• Grace O’Connell, American bioengineer
• Helen O'Connell (1920–1993), American singer, actress, and dancer
• Helen O'Connell (urologist) (born 1962), Australian urologist
• Jack O'Connell (disambiguation), multiple people
• Jerry O'Connell (born 1974), American actor
• Joe O'Connell (disambiguation), multiple people
• John O'Connell (disambiguation), multiple people
• Joseph O'Connell (disambiguation), multiple people
• Maeve O'Connell, Irish politician
• Martin O'Connell (disambiguation), multiple people
• Maura O'Connell (born (1958), Irish singer and actress, singer
• Maurice O'Connell (disambiguation), multiple people
• Muireann O'Connell, (born 1983), Irish broadcaster
• Max O'Connell (born 1936), Australian cricket umpire
• Mick O'Connell (born 1937), Irish footballer
• Millie O'Connell (born 1997) British Theatre actress and singer
• Mike O'Connell (born 1955), American ice hockey player and general manager
• Paddy or Pat or Patrick O'Connell (disambiguation), multiple people
• Paul O'Connell (born 1979), Irish rugby player
• Ryan O'Connell (brn 1986), American writer, actor, and producer
• Stephen C. O'Connell (1916–2001), Florida Supreme Court justice (1955–1967), president of the University of Florida (1967–1973)
• Taaffe O'Connell (born 1951), American actress and publisher
• Terri O'Connell (born 1964), American motor racing driver and transgender
• Thomas J. O'Connell (1882–1969), Irish politician
• William O'Connell (disambiguation), multiple people

• O'Connell of Derrynane, Gaelic Irish noble family
• O'Connell baronets

• William O'Connell Bradley (1847–1914), U.S. Senator from Kentucky
• Conal Holmes O'Connell O'Riordan (1874–1948), Irish dramatist and novelist

• Rick O'Connell, main character in American The Mummy films
• Maggie O'Connell, in American television series Northern Exposure
• Camille O’Connell, in American television series The Originals
• Brian O'Connal main character in Canadian Novel Who Has Seen The Wind
• Ocean O'Connell Rosenberg in Canadian musical Ride The Cyclone