North Slope can refer to:

• Alaska North Slope, a region encompassing the northernmost part of the U.S. state of Alaska
• North Slope Borough, Alaska, a borough in Alaska whose boundaries roughly coincide with that of the region
• North Slope, Tacoma, Washington, a neighborhood
• North Slope, an Inupiaq language dialect
• Alaska gas pipeline, also known as the North Slope Gas Pipeline
• Dalton Highway, also known as the North Slope Haul Road
• Prudhoe Bay Oil Field, colloquially known as "the North Slope" to many who work and visit there