New Madrid may refer to:

• New Madrid County, Missouri, a county in the U.S. state of Missouri
• New Madrid, Missouri, a city in New Madrid County
• New Madrid Seismic Zone, a major seismic zone in Missouri, Tennessee, and Arkansas
  • New Madrid earthquake, a series of four earthquakes that occurred in late 1811 and early 1812
• "New Madrid" (song), by Uncle Tupelo from their 1993 album Anodyne
• New Madrid, a literary journal published by Murray State University
• Birds Point-New Madrid Floodway