Nathan Smith may refer to:

• Nathan Smith (Irish cricketer) (born 1995), Irish cricketer
• Nathan Smith (New Zealand cricketer) (born 1998), New Zealand cricketer
• Nathan Smith (rugby league, born 1983), Australian rugby league player for Penrith Panthers
• Nathan Smith (rugby league, born 1988), Australian rugby league footballer for the Parramatta Eels
• Nathan Smith (footballer, born 1987), English-born Jamaican football player
• Nathan Smith (soccer, born 1994), American soccer player
• Nathan Smith (footballer, born 1996), English football player
• Nathan Smith (golfer) (born 1978), American amateur golfer
• Nate Smith (golfer) (born 1983), American professional golfer on the Nationwide Tour
• Nathan Smith (ice hockey, born 1982), Canadian NHL player
• Nathan Smith (ice hockey, born 1998), American Olympic hockey player
• Nathan Smith (biathlete) (born 1985), Canadian biathlete
• Nathan Smith (cyclist), British cyclo-cross cyclist

• Nathan Smith (politician) (1770–1835), U.S. Senator
• Nathan B. Smith (1841–1920), American lawyer and politician
• Nathan Lloyd Smith (1975–2002), Canadian soldier, killed in Afghanistan
• Nathan Smith (physician, born 1762) (1762–1829), U.S. physician, founder of several U.S. medical schools
• Nathan Ryno Smith (1797–1877), U.S. physician, professor at University of Maryland

• Nathaniel Smith (disambiguation)
• Nate Smith (disambiguation)