A motherboard is the main printed circuit board in a computer.

Motherboard may also refer to:

• Motherboard cache, the storage component of a motherboard
• Motherboard form factor, the specifications of a motherboard
• Motherboard (Cyberchase), a character from Cyberchase
• Motherboard (website), an online tech news publication by Vice Media
• "Motherboard" (Daft Punk song), 2013 song in album Random Access Memories
• Motherboard Monitor, a software program for Windows