Michael Ferguson or Mike Ferguson may refer to:

• Michael Ferguson (Irish politician) (1953–2006), Irish Sinn Féin politician who represented Belfast West
• Michael Ferguson (Australian politician) (born 1974), Australian politician
• Michael Ferguson (director) (1937–2021), British television director who worked on the BBC science fiction television series Doctor Who
• Michael Ferguson, Canadian policeman convicted for the manslaughter of Darren Varley
• Michael Ferguson (Auditor General) (1958–2019), Auditor General of Canada
• Michael Ferguson (Connecticut politician), member of the Connecticut House of Representatives
• Mick Ferguson (born 1954), former footballer from Newcastle, England
• Mike Ferguson (footballer) (1943–2019), footballer from Lancashire, England
• Mike Ferguson (politician) (born 1970), United States politician from New Jersey
• Michael Ferguson (biochemist) (born 1957), British biochemist, University of Dundee
• Mike Ferguson (golfer) (born 1952), Australian golfer