Main Street station may refer to:

• Main Street station (Toronto), a subway station in Toronto, Ontario, Canada
• Main Street–Science World station, a SkyTrain station in Vancouver, British Columbia, Canada

• Main Street railway station (Glasgow), in Glasgow, Scotland

• Main Street station (SEPTA), in Norristown, Pennsylvania, United States
• Main Street Station Hotel and Casino and Brewery, in Las Vegas, Nevada, United States
• Alma School/Main Street station, in Mesa, Arizona, United States
• Center/Main Street station, in Mesa, Arizona, United States
• Downers Grove Main Street station, in Downers Grove, Illinois, United States
• Evanston Main Street station, in Evanston, Illinois, United States
• Flushing–Main Street (IRT Flushing Line), in Queens, New York, United States
• Flushing–Main Street (LIRR station), in Queens, New York, United States
• Mesa Drive/Main Street station, in Mesa, Arizona, United States
• Richmond Main Street Station, in Richmond, Virginia, United States
• Southeast Main Street MAX Station, in Portland, Oregon, United States
• Sycamore/Main Street station, in Mesa, Arizona, United States

• Main Street (disambiguation)
• Main station (disambiguation)
• All pages with titles containing Main Avenue Station
• All pages with titles beginning with Main Street station
• All pages with titles containing Main Street station