MT-7716
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| IUPAC name 2-[3-[1-[(1R)-1,2-Dihydroacenaphthylen-1-yl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide | |
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| Properties | |
| C27H28N4O2 | |
| Molar mass | 440.547 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
MT-7716 is an experimental opioid drug that could potentially be used in the treatment of alcohol addiction.
Mechanism of action
Unlike most opioids, MT-7716 does not appear to act through delta, kappa and mu opioid receptors, but instead is an agonist of the nociceptin receptor.[1]
Alcohol addiction
A study has shown that MT-7716 was able to decrease alcohol self-administration and reduce alcohol withdrawal symptoms in rats.[2]
Another study was also able to show similar results, in addition to demonstrating MT-7716's ability to suppress stress-induced alcohol seeking.[3]
References
- ^ Kallupi, Marsida; Oleata, Christopher S.; Luu, George; Teshima, Koji; Ciccocioppo, Roberto; Roberto, Marisa (2014). "MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala". Frontiers in Integrative Neuroscience. 8: 18. doi:10.3389/fnint.2014.00018. ISSN 1662-5145. PMC 3927450. PMID 24600360.
- ^ Ciccocioppo, Roberto; Stopponi, Serena; Economidou, Daina; Kuriyama, Makoto; Kinoshita, Hiroshi; Heilig, Markus; Roberto, Marisa; Weiss, Friedbert; Teshima, Koji (April 2014). "Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat". Neuropsychopharmacology. 39 (11): 2601–2610. doi:10.1038/npp.2014.113. ISSN 1740-634X. PMC 4207340. PMID 24863033.
- ^ de Guglielmo, Giordano; Martin-Fardon, Rémi; Teshima, Koji; Ciccocioppo, Roberto; Weiss, Friedbert (July 2015). "MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats". Addiction Biology. 20 (4): 643–651. doi:10.1111/adb.12157. ISSN 1355-6215. PMC 4268094. PMID 24930632.
