MMP26

MMP26
Identifiers
Aliases	MMP26, matrix metallopeptidase 26
External IDs	OMIM: 605470; HomoloGene: 49684; GeneCards: MMP26; OMA:MMP26 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	4,992,431 bp
RNA expression pattern
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	56547
	n/a
	ENSG00000167346
	n/a
	Q9NRE1
	n/a
	NM_021801; NM_001384608
	n/a
	NP_068573
	n/a
	Wikidata
View/Edit Human

Matrix metalloproteinase-26 also known as matrilysin-2 and endometase is an enzyme that in humans is encoded by the MMP26 gene.^[3]^[4]^[5]

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin (A1AT), alpha 2-macroglobulin (A2M), and insulin-like growth factor-binding protein 1 (IGFBP), and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167346 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Park HI, Ni J, Gerkema FE, Liu D, Belozerov VE, Sang QX (Aug 2000). "Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor". J Biol Chem. 275 (27): 20540–4. doi:10.1074/jbc.M002349200. PMID 10801841.
^ de Coignac AB, Elson G, Delneste Y, Magistrelli G, Jeannin P, Aubry JP, Berthier O, Schmitt D, Bonnefoy JY, Gauchat JF (Jul 2000). "Cloning of MMP-26. A novel matrilysin-like proteinase". Eur J Biochem. 267 (11): 3323–9. doi:10.1046/j.1432-1327.2000.01363.x. PMID 10824119.
^ ^a ^b "Entrez Gene: MMP26 matrix metallopeptidase 26".

Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448.
Uría JA, López-Otín C (2000). "Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity". Cancer Res. 60 (17): 4745–51. PMID 10987280.
Marchenko GN, Ratnikov BI, Rozanov DV, et al. (2001). "Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin". Biochem. J. 356 (Pt 3): 705–18. doi:10.1042/0264-6021:3560705. PMC 1221897. PMID 11389678.
Gearing AJ, Thorpe SJ, Miller K, et al. (2002). "Selective cleavage of human IgG by the matrix metalloproteinases, matrilysin and stromelysin". Immunol. Lett. 81 (1): 41–8. doi:10.1016/S0165-2478(01)00333-9. PMID 11841844.
Marchenko ND, Marchenko GN, Strongin AY (2002). "Unconventional activation mechanisms of MMP-26, a human matrix metalloproteinase with a unique PHCGXXD cysteine-switch motif". J. Biol. Chem. 277 (21): 18967–72. doi:10.1074/jbc.M201197200. PMID 11889136.
Marchenko GN, Marchenko ND, Leng J, Strongin AY (2002). "Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin". Biochem. J. 363 (Pt 2): 253–62. doi:10.1042/0264-6021:3630253. PMC 1222473. PMID 11931652.
Park HI, Turk BE, Gerkema FE, et al. (2002). "Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26". J. Biol. Chem. 277 (38): 35168–75. doi:10.1074/jbc.M205071200. PMID 12119297.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhao YG, Xiao AZ, Newcomer RG, et al. (2003). "Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells". J. Biol. Chem. 278 (17): 15056–64. doi:10.1074/jbc.M210975200. PMID 12586837.
Chegini N, Rhoton-Vlasak A, Williams RS (2003). "Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout the normal menstrual cycle and alteration in users of levonorgestrel implants who experience irregular uterine bleeding". Fertil. Steril. 80 (3): 564–70. doi:10.1016/S0015-0282(03)00797-0. PMID 12969699.
Park HI, Jin Y, Hurst DR, et al. (2004). "The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling". J. Biol. Chem. 278 (51): 51646–53. doi:10.1074/jbc.M310109200. PMID 14532275.
Zhao YG, Xiao AZ, Park HI, et al. (2004). "Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion". Cancer Res. 64 (2): 590–8. doi:10.1158/0008-5472.CAN-03-1932. PMID 14744773. S2CID 15342778.
Pilka R, Domanski H, Hansson S, et al. (2005). "Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26". Mol. Hum. Reprod. 10 (9): 641–50. doi:10.1093/molehr/gah092. PMID 15273280.
Yamamoto H, Vinitketkumnuen A, Adachi Y, et al. (2005). "Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma". Carcinogenesis. 25 (12): 2353–60. doi:10.1093/carcin/bgh270. PMID 15333466.
Pilka R, Norata GD, Domanski H, et al. (2004). "Matrix metalloproteinase-26 (matrilysin-2) expression is high in endometrial hyperplasia and decreases with loss of histological differentiation in endometrial cancer". Gynecol. Oncol. 94 (3): 661–70. doi:10.1016/j.ygyno.2004.05.024. PMID 15350356.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Li W, Savinov AY, Rozanov DV, et al. (2005). "Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin". Cancer Res. 64 (23): 8657–65. CiteSeerX 10.1.1.316.8634. doi:10.1158/0008-5472.CAN-04-3019. PMID 15574774. S2CID 33047996.

External links

The MEROPS online database for peptidases and their inhibitors: M10.029

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167346 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10801841-3] Park HI, Ni J, Gerkema FE, Liu D, Belozerov VE, Sang QX (Aug 2000). "Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor". J Biol Chem. 275 (27): 20540–4. doi:10.1074/jbc.M002349200. PMID 10801841.

[pmid10824119-4] Coignac AB, Elson G, Delneste Y, Magistrelli G, Jeannin P, Aubry JP, Berthier O, Schmitt D, Bonnefoy JY, Gauchat JF (Jul 2000). "Cloning of MMP-26. A novel matrilysin-like proteinase". Eur J Biochem. 267 (11): 3323–9. doi:10.1046/j.1432-1327.2000.01363.x. PMID 10824119.

[entrez-5] "Entrez Gene: MMP26 matrix metallopeptidase 26".

[1]

[2]

[3]

[4]

[5]

Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Fahrer / Team für die Suche eingeben:

Fahrer / Team für die Suche eingeben:

Eisspeedway

MMP26

Function

References

Further reading

External links