Luthra is a surname originating with the Khatri Arora Hindu and Sikh communities of the Punjab. It is part of the broad Kshatriya caste. The Kshatriyas in Hinduism are one of the four varnas. They are traditionally members of the military or ran in an administrative capacity. The Kshatriya were assigned to protecting the Hindu dharma. They are from the Aryan race and have been ruling in the past through their kingdoms.

Today, Luthras live in numerous regions within India, but are mostly concentrated in Punjab, Haryana, Delhi and Uttar Pradesh. Luthras can be both Sikh and Hindu, as the religions are generally very close in the Punjab region. Luthras have also immigrated to various countries, with a notable population in Canada, United Kingdom, United States and Australia

Notable people bearing the surname include:

• Amit Luthra (born 1960), Indian golfer
• Arun Luthra Indo-Anglo-American musician (saxophonist, konnakol artist, composer, arranger)
• Balvir Singh Luthra, Indian film director and screenwriter
• Balvir Singh Luthra, Indian politician and farmer in Rajasthan
• Geeta Luthra, Indian lawyer
• Girish Luthra, Indian Navy officer, Flag Officer Commanding-in-Chief, Western Command from 2016 to 2019
• Nishchay Luthra (born 1999), Indian figure skater
• Pran Nath Luthra (1917–2000), Indian civil service officer and writer
• Salony Luthra, Indian actress
• Sargun Kaur Luthra, Indian actress
• Sidharth Luthra (born 1966), Indian advocate at the Supreme Court of India
• Suresh Luthra (1944–1019), Indian cricketer
• Usha Kehar Luthra (born 1932), Indian pathologist and cytologist
• Vandana Luthra (born 1959), Indian entrepreneur, founder of VLCC Health Care Ltd