The Districts of South Sulawesi are the administrative divisions of South Sulawesi, a province of Indonesia that is made up of 21 regencies (kabupaten) and 3 independent cities (kota), which are both in turn divided into districts called Kecamatan.

Five years after independence, the government issued Law No. 21 of 1950, which became the basis of the legal establishment for what was then the Sulawesi province. Ten years later, the government passed Law No. 47 of 1960 which endorsed the formation of the South/Southeast Sulawesi province. Four years after that, with Act No. 13 of 1964, the provinces of South Sulawesi and Southeast Sulawesi were separated. Forty years later, the South Sulawesi government was split into two, with the regencies of Majene, Mamasa, Mamuju, Pasangkayu, and Polewali Mandar having been separated off to form a new West Sulawesi province on 5 October 2004 under Act No. 26 of 2004.

The South Sulawesi Province is composed of two major regions. The first - the southern half - consists of the southern peninsula itself and comprises sixteen regencies plus the independent cities of Makassar and Parepare. The second - the more mountainous and less densely populated northern half - now comprises five regencies plus the independent city of Palopo.

Three new regencies and a city have been created in this northern half since the establishment of the province. A new regency (Luwu Utara) was created on 20 April 1999 from the northern part of the existing Luwu Regency; a new city (Palopo) was created on 10 April 2002 from a further part of Luwu Regency; and on 25 February 2003 another regency (Luwu Timur) was formed from the eastern half of the Luwu Utara Regency. Following the splitting away of part (five regencies) of the province to form a separate West Sulawesi Province in 2004, the remaining South Sulawesi Province was divided into twenty regencies (kabupaten) and three independent cities (kota), but a twenty-first regency (Toraja Utara) was formed on 24 June 2008 from the northern half of Tana Toraja Regency.

These regencies and cities are listed below with their areas and their populations as of the 2010 Census^[1] and 2020 Census,^[2] together with the official estimates as at mid 2023.^[3] The table also includes the number of districts (kecamatan) in each regency or city, its administrative capital and its Human Development Index for 2018.

Notes: (a) The 2000 Census population for East Luwu Regency is included in the figure for North Luwu Regency, from which it was formed on 25 February 2003 (under Law No.7 of 2003).
(b) The 2000 Census population for North Toraja Regency is included in the figure for Tana Toraja Regency, from which it was formed on 26 November 2008 (under Law No.28 of 2008, following the publication of the report of Commission President Yudhoyono, numbered R.68/Pres/12/2007 on 10 December 2007, regarding the expansion of the twelve original districts and cities).
(c) The 2000 Census population for Palopo city is included in the figure for Luwu Regency, from which it was formed on 10 April 2002 (under Law No.11 of 2002).

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The 307 districts (kecamatan) of South Sulawesi are as follows, listed with the regencies or cities in which they are situated: