Langat virus
| Langat virus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Kitrinoviricota |
| Class: | Flasuviricetes |
| Order: | Amarillovirales |
| Family: | Flaviviridae |
| Genus: | Flavivirus |
| Species: | Langat virus |
Langat virus (LGTV) is a virus of the genus Flavivirus. The virus was first isolated in Malaysia in 1956 from a hard tick of the Ixodes genus.[1] This virus is antigenically related to Omsk hemorrhagic fever virus, Kyasanur forest disease virus, Alkhurma virus, Louping ill virus and other viruses of the tick-borne encephalitis virus (TBEV) complex. The Langat virus does not pose a significant epidemiological threat in comparison with TBEV. There are no known cases of human diseases associated with LGTV.[2] The Malaysian strain (LGT strain TP21, also known as the Yelantsev virus) is naturally attenuated and induces neutralizing antibodies to tick-borne encephalitis virus (TBEV) and protection against other TBEV complex viruses in animals.[3]
LGTV-based vaccine
In the 1970s a live attenuate LGTV-based vaccine against tick-borne encephalitis was made. At the same time, another vaccine was tested, but the group vaccinated with the LGTV-based vaccine had the lowest level of developing infection decease.[4] However, there were two major problems: the relatively high rate of incidents of encephalitis (1:10,000) and lack of absolute protection from infection in endemic regions.[citation needed]
References
- ^ Smith, CE (15 September 1956). "A virus resembling Russian spring-summer encephalitis virus from an ixodid tick in Malaya". Nature. 178 (4533): 581–2. Bibcode:1956Natur.178..581G. doi:10.1038/178581a0. PMID 13369466. S2CID 4272594.
- ^ Gritsun TS, Lashkevich VA, Gould EA (January 2003). "Tick-borne encephalitis". Antiviral Res. 57 (1–2): 129–46. doi:10.1016/S0166-3542(02)00206-1. PMID 12615309.
- ^ Rumyantsev, A. A.; Murphy, B. R.; Pletnev, A. G. (13 January 2006). "A Tick-Borne Langat Virus Mutant That Is Temperature Sensitive and Host Range Restricted in Neuroblastoma Cells and Lacks Neuroinvasiveness for Immunodeficient Mice". Journal of Virology. 80 (3): 1427–39. doi:10.1128/JVI.80.3.1427-1439.2006. PMC 1346960. PMID 16415020.
- ^ Shapoval AN; Kamalov II; Denisova EIu; Sokolova ED; Luzin PM; Shamarina AG; Gusmanova AG; Pinaeva NI (1989). "Study of the distant consequences of immunizing people with a live vaccine against tick-borne encephalitis". Tr Inst Im Pastera (in Russian). 65: 133–5. PMID 2629181.