John Radcliffe may refer to:

• John Radcliffe (died 1441), Member of Parliament for Norfolk
• John Radcliffe (died 1568) (1539–1568), MP for Grampound and Castle Rising
• John Q. Radcliffe (1920–2001), Wisconsin State Assemblyman
• John Radcliffe (1738-1783) (1738–1783), British politician who sat in the House of Commons from 1768 to 1783

• John Radcliffe (physician) (1652–1714), British physician
  • John Radcliffe Hospital, Oxford, named after the above
• John Netten Radcliffe (1826–1884), English epidemiologist
• John Radcliff (1848–1911), American baseball player

• John Radclive, Canadian hangman
• John Ratcliffe (disambiguation)