James Christopher Harrison OAM (born 27 December 1936), also known as the Man with the Golden Arm, is a blood plasma donor^[2] from Australia whose plasma contains antibodies against RhD which are used in making a treatment for Rhesus disease. One of the founding donors of New South Wales' (NSW) Rh Program, he regularly donated until, on 11 May 2018, he made his 1,173rd donation^[3][4] – his last, as Australian policy then prohibited blood donations from those past age 81.^[5]

James Harrison was born on 27 December 1936.^[6] In 1951, at the age of 14, he underwent major chest surgery, requiring a large amount of blood. Realizing that the blood had saved his life, he made a pledge to start donating blood himself as soon as he turned 18, the then-required age.^[7][8]

Harrison started donating in 1954. After the first few donations, it was discovered that his blood contained unusually strong and persistent antibodies against the D Rh group antigen. Blood which contains a high level of anti-D antibodies can be processed to create immunoglobulin-based products used to prevent haemolytic disease of the newborn (HDN). These products are given to Rh(D) negative mothers of unknown or Rh(D) positive babies during and after pregnancy to prevent the creation of antibodies to the blood of the Rh(D) positive child. This antigen sensitization and subsequent incompatibility phenomenon causes Rhesus disease, the most common form of HDN.^[4]

Harrison was one of the founding donors in NSW's Rh Program, one of the first in the world in 1969, and he had continuously donated from then onwards. As blood plasma, in contrast with blood, can be donated as often as once every two weeks, he was able to reach his 1,000th donation in May 2011. This resulted in an average of one donation every three weeks across 57 years. Commenting on his record, he said: "I could say it's the only record that I hope is broken, because if they do, they have donated a thousand donations".^[2] On 11 May 2018, he made his 1,173rd and last donation in compliance with Australian policy prohibiting blood donations from those past age 81.^[5]

Through their donations, the members of NSW's Rh Program have provided millions of doses of anti-D and helped prevent thousands of deaths and stillbirths, as well as many more instances of sickness and disability caused by HDN. Over his lifetime, Harrison's donations amounted to tens of thousands of doses worth of antibodies and had contributed to every batch of anti-D produced in NSW.^[4]

Research is also being done on creating a mixture of monoclonal antibodies, antibodies made by immortalised B cells in bioreactors, that matches what is naturally produced in the bodies of donors such as Harrison. The project has been colloquially called "James in a Jar".^[9]

In 2007, Harrison was critical of plans to open up Australia's plasma donation to foreign corporations. He believes that opening up the trade will discourage volunteer donations. This opening of trade stemmed from a review of the country's free trade agreement with the United States.^[10]

Harrison was awarded the Medal of the Order of Australia (OAM) on 7 June 1999.^[11] In 2011, he was nominated in the New South Wales Local Hero division of the Australian of the Year awards.^[6]