Irvine F.C. may refer to:

• Irvine F.C. (1875), a former association football club from Irvine, North Ayrshire which existed from 1875–1881.
• Irvine F.C. (1877), a former association football club from Irvine, North Ayrshire which existed from 1877–1899.
• Irvine Meadow XI F.C., an association football club from Irvine, North Ayrshire which plays in the West of Scotland Football League.
• Irvine Victoria F.C., an association football club from Irvine, North Ayrshire which plays in the West of Scotland Football League.
• Irvine RFC, a rugby union club from Irvine, North Ayrshire.