Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3gene.[5][6] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.[7]
Rosati O, Martin MU (May 2002). "Identification and characterization of murine IRAK-M". Biochemical and Biophysical Research Communications. 293 (5): 1472–7. doi:10.1016/S0006-291X(02)00411-4. PMID12054681.
Escoll P, del Fresno C, García L, Vallés G, Lendínez MJ, Arnalich F, López-Collazo E (November 2003). "Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients". Biochemical and Biophysical Research Communications. 311 (2): 465–72. doi:10.1016/j.bbrc.2003.10.019. PMID14592437.
Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G (June 2007). "IRAK-M is involved in the pathogenesis of early-onset persistent asthma". American Journal of Human Genetics. 80 (6): 1103–14. doi:10.1086/518259. PMC1867098. PMID17503328.
Weersma RK, Oostenbrug LE, Nolte IM, Van Der Steege G, Oosterom E, Van Dullemen HM, Kleibeuker JH, Dijkstra G (July 2007). "Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases". Scandinavian Journal of Gastroenterology. 42 (7): 827–33. doi:10.1080/00365520601114024. PMID17558906. S2CID22703718.
