Gaona is a Spanish surname. It may refer to:

People

• Álvaro Gaona (born 1985), Mexican boxer
• Antonio Gaona (general) (1793–1848), Mexican general
• Antonio Gaona (actor) (born 1982), Mexican actor
• Citlalli Gaona-Tiburcio, Mexican materials scientist
• Jorge Gaona (born 1985), Paraguayan footballer
• José Julio Gaona (born 1943), Mexican painter
• Juan de Gaona (1507–1560), Spanish Franciscan and Mesoamericanist
• Julio César Gaona (born 1973), Argentine footballer
• Octavio Gaona (1907–1996), Mexican professional wrestler
• Orlando Gaona Lugo (born 1990), Paraguayan footballer

Places

• Gaona, Argentina, village and rural municipality in Salta Province