Protein-coding gene in the species Homo sapiens
Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene .[ 5]
GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos . The roof plate is required for the generation of several classes of spinal cord dorsal interneurons ; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.[ 5] [ 6]
GDF7 is also known as bone morphogenic protein 12 (BMP-12 ).[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000143869 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037660 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Lee KJ, Mendelsohn M, Jessell TM (November 1998). "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord" . Genes Dev . 12 (21): 3394–407. doi :10.1101/gad.12.21.3394 . PMC 317230 PMID 9808626 . ^ Lo L, Dormand E, Anderson D (2005). "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7" . Proc Natl Acad Sci USA . 102 (20): 7192–7. Bibcode :2005PNAS..102.7192L . doi :10.1073/pnas.0502581102 PMC 1091754 PMID 15883363 . ^ Peng C, Lei C, Guofei C, Tian Y, Wei L, Jianwei Z, Chen W, Wentao Z, Changqing J (2019). "The application of BMP-12-overexpressing mesenchymal stem cells loaded 3D-printed PLGA scaffolds in rabbit rotator cuff repair". International Journal of Biological Macromolecules . 138 : 79–88. doi :10.1016/j.ijbiomac.2019.07.041 . PMID 31295489 . S2CID 195892657 .
Further reading
Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun . 11 (3): 232–8. doi :10.1038/gene.2010.1 . PMID 20237496 . S2CID 11183658 . Davidson AJ, Postlethwait JH, Yan YL, et al. (1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily" . Genome Res . 9 (2): 121–9. doi :10.1101/gr.9.2.121 PMID 10022976 . Butler SJ, Dodd J (2003). "A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons" . Neuron . 38 (3): 389–401. doi :10.1016/S0896-6273(03)00254-X PMID 12741987 . S2CID 6434429 . Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses" . J. Biol. Chem . 280 (37): 32122–32. doi :10.1074/jbc.M504629200 PMID 16049014 . S2CID 23693180 .
Type I
ALK1 (ACVRL1 )ALK2 (ACVR1A )ALK3 (BMPR1A )ALK4 (ACVR1B )ALK5 (TGFβR1 )ALK6 (BMPR1B )
Agonists: BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )Dibotermin alfa Eptotermin alfa GDF (5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 15 )Radotermin ALK7 (ACVR1C )
Type II
TGFβR2 BMPR2 ACVR2A (ACVR2 )
Agonists: Activin (A , B , AB )BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )Dibotermin alfa Eptotermin alfa GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 11 (BMP11) , 15 )Myostatin (GDF8) Nodal Radotermin ACVR2B
Agonists: Activin (A , B , AB )BMP (2 , 4 , 6 , 7 )Dibotermin alfa Eptotermin alfa GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) )Myostatin (GDF8) Nodal Osteogenin (BMP3, BMP3A) Radotermin AMHR2 (AMHR )
Type III
Unsorted
