Frank Gallagher may refer to:

• Frank Gallagher (actor) (born 1962), Scottish actor
• Frank Gallagher (American football) (born 1943), professional American football player
• Frank Gallagher (author) (1893–1962), Irish journalist, editor
• Frank Gallagher (Brooklyn) (1870–1932), New York politician
• Frank Gallagher (ice hockey), Canadian–American ice hockey executive
• Frank Gallagher (rugby league) (died 1966), rugby league footballer of the 1920s for Great Britain, England, Yorkshire, Dewsbury, Batley, and Leeds
• Frank T. Gallagher (1887–1977), American jurist
• Frankie Gallagher, Northern Irish politician
• Frank Gallagher (Shameless), a fictional character in the British TV series Shameless
• Frank Gallagher, birth name of Medal of Honor recipient Francis T. Ryan (1862–1927)