Fixed drug reaction
| Fixed drug reaction | |
|---|---|
| Other names | Drug eruption |
 | |
| Fixed drug eruption caused by phenolphtalein. | |
| Specialty | Dermatology  |
Fixed drug reactions are common and so named because they recur at the same site with each exposure to a particular medication.[1] Medications inducing fixed drug eruptions are usually those taken intermittently.[1]
Signs and symptoms
A painful and itchy reddish/purple patch of skin that occurs in the same location with repeated exposures to the causative drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.
Cause
Medications that are commonly implicated as a cause of fixed drug eruptions include the following:
- Cetirizine
- Ciprofloxacin
- Clarithromycin
- Cotrimoxazole
- Doxycycline
- Fluconazole
- NSAIDs (e.g., ibuprofen, etoricoxib, naproxen)
- Phenytoin
- Pseudoephedrine[2]
- Trimethoprim
See also
- Drug eruption
- List of cutaneous conditions
- List of human leukocyte antigen alleles associated with cutaneous conditions
- Stevens–Johnson syndrome
References
- ^ a b James W, Berger T, Elston D (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. p. 127. ISBN 978-0-7216-2921-6.
- ^ Vidal C, Prieto A, Pérez-Carral C, Armisén M (April 1998). "Nonpigmenting fixed drug eruption due to pseudoephedrine". Annals of Allergy, Asthma & Immunology. 80 (4): 309–310. doi:10.1016/S1081-1206(10)62974-2. PMID 9564979.