Protein-coding gene in the species Homo sapiens
E74-like factor 2 (ELF2 ), formerly known as new Ets-related factor (NERF ), is an ETS family transcription factor .[ 5] protein is encoded by the ELF2 gene .[ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000109381 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037174 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA (September 1996). "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1" . Mol. Cell. Biol . 16 (9): 5091–106. doi :10.1128/MCB.16.9.5091 . PMC 231510 PMID 8756667 . ^ "Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor)" .
Further reading
Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia" . Leukemia . 11 (1): 86–96. doi :10.1038/sj.leu.2400516 PMID 9001422 . Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias" . Mol. Cell. Biol . 19 (5): 3635–44. doi :10.1128/mcb.19.5.3635 . PMC 84165 PMID 10207087 . Christensen RA, Fujikawa K, Madore R, et al. (2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem . 85 (3): 505–15. doi :10.1002/jcb.10148 . PMID 11967990 . S2CID 36902890 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene" . J. Biol. Chem . 279 (19): 19512–22. doi :10.1074/jbc.M309074200 PMID 14970218 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Zhang B, Tomita Y, Qiu Y, et al. (2007). "E74-like factor 2 regulates valosin-containing protein expression". Biochem. Biophys. Res. Commun . 356 (3): 536–41. doi :10.1016/j.bbrc.2007.02.160 . PMID 17368566 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
