EDN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EDN, 1EDP, 1T7H, 1V6R, 6DK5, 5GLH
Identifiers
Aliases	EDN1, ARCND3, ET1, HDLCQ7, QME, endothelin 1, PPET1
External IDs	MGI: 95283; HomoloGene: 1476; GeneCards: EDN1; OMA:EDN1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.1 Start 12,290,361 bp[1] End 12,297,194 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A4|13 20.82 cM Start 42,454,952 bp[2] End 42,461,466 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Top expressed in More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1906 13614 Ensembl ENSG00000078401 ENSMUSG00000021367 UniProt P05305 P22387 RefSeq (mRNA) NM_001168319 NM_001955 NM_010104 RefSeq (protein) NP_001161791 NP_001946 NP_001161791 NP_001946 NP_034234 Location (UCSC) Chr 6: 12.29 – 12.3 Mb Chr 13: 42.45 – 42.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor peptide produced by vascular endothelial cells,^[5] as well as by cells in the heart (affecting contractility) and kidney (affecting sodium handling).^[6] The protein encoded by this gene – EDN1 – is proteolytically processed to release endothelin 1. Endothelin 1 is one of three isoforms of human endothelin.

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.^[5][7]

Patients with salt-sensitive hypertension have higher plasma ET-1.^[6] Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension.^[5] Use of these antagonists prevents pulmonary arterial constriction and thus inhibits pulmonary hypertension.^[5]

As of 2020, the role of endothelin-1 in affecting lipid metabolism and insulin resistance in obesity mechanisms was under clinical research.^[8]

• Overview of all the structural information available in the PDB for UniProt: P05305 (Endothelin-1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.